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英文名稱    DAF16    
中文名稱    衰變加速因子蛋白16抗體    
別    名    DAF-16; DAF 16; Decay Accelerating Factor16.    
研究領域    細胞生物  發(fā)育生物學  信號轉導  新陳代謝      
抗體來源    Rabbit    
克隆類型    Polyclonal    
交叉反應    Human, Mouse, Rat, elegans    
產(chǎn)品應用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 衰變加速因子蛋白16抗體（石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    
分 子 量    42-48kDa    
性    狀    Lyophilized or Liquid    
濃    度    1mg/1ml    
免 疫 原    KLH conjugated synthetic peptide derived from human DAF16/Decay Accelerating Factor16    
亞    型    IgG    
純化方法    affinity purified by Protein A    
儲 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

衰變加速因子蛋白16抗體簡介 background:
DAF-2, DAF-16 and AGE-1 (also known as DAF-23) regulate lifespan via an insulin-signaling pathway. In specific, decreases in DAF-2 signaling induce metabolic and developmental changes, as in mammalian metabolic control by the insulin receptor. DAF-16 encodes a member of the hepatocyte nuclear factor 3 (HNF-3)/forkhead family of transcriptional regulators. In humans HNF-3 activity is antagonized by insulin, causing the down regulation of developmental genes, raising the possibility that aspects of the DAF-16 regulatory system have been conserved. The gene AGE-1 encodes a homologue of mammalian phosphatidylinositol-3-OH kinase (PI(3)K) catalytic subunits and is required fornon-dauer development and normal senescence. CLK-1, a homolog of the yeast COQ7/CAT5 protein, is thought to exert its effects on longevity via the synthesis of ubiquinone, an essential component of electron transport.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.